Lasse Lindahl

The paper compares transcriptome changes in yeast when ribosome formation is inhibited versus ribosome function is inhibited, finding distinct gene expression patterns.

The paper shows that disrupting 40S ribosomal assembly leads to accumulation of extra-ribosomal 60S protein uL18/L5, challenging the expectation that such accumulation only occurs during 60S assembly disruption.

The paper shows that cells regulate ribosomal subunit balance by halting 40S accumulation when 60S assembly is impaired and degrading excess 40S subunits.

The paper compares gene expression patterns under ribosomal and translational stress to determine the underlying mechanisms of cell cycle arrest.