Jessica C. Orr

This study shows that p63 regulates stem cell function in human airway basal cells and declines with age, contributing to functional decline and reduced regenerative capacity.

This study identifies podoplanin (PDPN) as a marker for human airway basal cells with high progenitor potential, enabling efficient sorting of airway stem cells.

The paper introduces WS6 to enhance ex vivo expansion and gene editing of epithelial basal stem cells, enabling disease modeling and regenerative medicine applications.

The paper screens 1,429 compounds in primary human airway basal cells to identify Wnt pathway activators that promote proliferation and regeneration.

This paper develops lentiviral reporter constructs to quantitatively monitor airway epithelial cell differentiation using bioluminescence in vitro.