Robert E. Hynds

Critical role for the TGF-β1/mTORC1 signalling axis in defining the transcriptional identity of CTHRC1+ pathologic fibroblasts

This study shows that the TGF-β1/mTORC1 signalling axis regulates the transcriptional identity of CTHRC1+ fibroblasts in IPF, supporting mTORC1 as a therapeutic target.

p63 regulates stem cell maintenance and age-associated functional decline in human airway basal cells

This study shows that p63 regulates stem cell function in human airway basal cells and declines with age, contributing to functional decline and reduced regenerative capacity.

Neutrophil myeloperoxidase as a functional biomarker for RSV severity: implications for in vitro therapeutic screening.

This study identifies neutrophil myeloperoxidase (MPO) as a biomarker for RSV severity and demonstrates its utility as a functional readout for evaluating antiviral therapies in an in vitro model.

Donor-derived airway ALI model for high-throughput screening of antiviral combinations with concurrent analysis of antiviral efficacy and epithelial toxicity using ciliR

The paper presents a donor-derived air-liquid interface model for screening antiviral combinations against RSV, with tools to assess efficacy and epithelial toxicity.

Podoplanin expression identifies human airway basal cells with higher progenitor cell potential

This study identifies podoplanin (PDPN) as a marker for human airway basal cells with high progenitor potential, enabling efficient sorting of airway stem cells.

Cell migration sculpts evolutionary dynamics favouring therapy resistance in lung cancer

This study shows that cell migration and stromal fibroblasts influence subclone competition in lung cancer, promoting therapy resistance through increased cell mixing.

WS6 enables scalable ex vivo expansion and gene editing of epithelial basal stem cells

The paper introduces WS6 to enhance ex vivo expansion and gene editing of epithelial basal stem cells, enabling disease modeling and regenerative medicine applications.

Compound screening in primary human airway basal cells identifies Wnt pathway activators as potential pro-regenerative therapies

The paper screens 1,429 compounds in primary human airway basal cells to identify Wnt pathway activators that promote proliferation and regeneration.

RAS-PI3K signaling promotes myofibroblastic CAF identity and restrains an immunomodulatory stromal program

This study identifies RAS-PI3K signaling as a key regulator of myofibroblastic CAF identity and matrix competence in lung cancer, showing its role in restraining immunomodulatory stromal programs.