ATR and PKMYT1 inhibition re-sensitize a subset of TNBC patient-derived models to carboplatin inducing mitotic catastrophe
Juliet Guay, Hellen Kuasne, Catherine Chabot, Kathryn Bozek, Yasamin Majedi, Marguerite Buchanan, Adriana Aguilar‐Mahecha, Eric Bareke, Benjamin Ulmer, Tim Kong, Kangning Yang, Minyan Liao, Oluwadara O. Elebute, Ruining Guo, Anie Monast, , Mark Basik
This study identifies ATR and PKMYT1 as targets to overcome carboplatin resistance in TNBC by re-sensitizing resistant models to carboplatin through mitotic catastrophe.
Cancer Research Communications · Apr 13, 2026Peer-reviewedCancer Biology