Anie Monast

Single-cell gene programs define subtype identity and metastatic trajectories in renal cell carcinoma

This study identifies 59 gene expression programs in RCC that reveal subtype identity and metastatic trajectories, including a metastatic signature linked to poor clinical outcomes.

ATR and PKMYT1 inhibition re-sensitize a subset of TNBC patient-derived models to carboplatin inducing mitotic catastrophe

This study identifies ATR and PKMYT1 as targets to overcome carboplatin resistance in TNBC by re-sensitizing resistant models to carboplatin through mitotic catastrophe.

EZH2 Inhibition Induces a Metabolic Stress Response Sensitizing TNBC to Glutaminase Targeting

This study shows that EZH2 inhibition in TNBC causes metabolic stress, making cells more sensitive to glutaminase inhibitors.