MicrobiologybioRxivPreprint
Mycobacterium tuberculosis, Mycobacterium kansasii and Rhodococcus equi induce macrophage necroptosis in the presence of a caspase inhibitor acting on a non-canonical target(s)
Rong Hu, Pei Li, Jie Han…·Li Zhang
This study shows that z-VAD induces necroptosis in macrophages infected with Mtb, M. kansasii, and R. equi by acting on non-canonical targets, and MLKL deficiency reduces TB pathology in susceptible mice.
DOI 10.1101/2025.09.02.673674