Hydroxyurea induces ER stress and cytoplasmic protein aggregation
Ana Sánchez-Molina, Manuel Bernal, Joel D. Posligua-García, Antonio J. Pérez‐Pulido, Laura de Cubas, Elena Hidalgo, M.‐Henar Valdivieso, Silvia Salas-Pino, Rafael R. Daga
This study shows hydroxyurea induces ER stress and cytoplasmic protein aggregation through disulfide stress, leading to ER expansion and HSP accumulation.
PLoS Biology · Nov 19, 2025Peer-reviewedCell Biology