Antonio J. Pérez‐Pulido

This paper develops a preclinical treatment for PTSD using a peptide that blocks CPEB3 amyloid formation, reducing traumatic memory consolidation and PTSD-like symptoms in mice.

This study shows that the bacterial ompW gene family expands through duplication and horizontal transfer, enabling functional diversification during host adaptation.

Sma3s v3 improves functional annotation of proteomes, pangenomes, and metagenomes by scaling annotation workflows and outperforming existing tools.

The paper identifies a stress-response integrative and conjugative element (ICE) in Sphingopyxis granuli TFA that is conserved across related bacterial orders and contributes to bacterial resilience under stress.

This study shows hydroxyurea induces ER stress and cytoplasmic protein aggregation through disulfide stress, leading to ER expansion and HSP accumulation.

The paper analyzes defense systems in Acinetobacter baumannii genomes and finds that innate systems influence prophage distribution and genome evolution.

The paper describes a virus in Acinetobacter baumannii that uses a CRISPR-Cas system to compete with another virus for genomic integration sites, revealing a form of viral warfare and insights into CRISPR-Cas system spread.

The paper reduces CRISPR dark matter by analyzing spacers in antibiotic-resistant bacterial genomes and links CRISPR-Cas systems to membrane proteins involved in phage defense.

This study demonstrates the use of SpG and SpRY CRISPR-Cas9 variants in zebrafish and C. elegans for genome editing, showing improved accessibility to previously uneditable sites.

The paper introduces ASACO, a tool for co-expression analysis of genes across transcriptomics data, identifies host factors involved in SARS-CoV infection, and validates findings against high-throughput screens.