Elena Hidalgo

Evolutionary emergence and preservation of microproteins encoded by upstream ORFs

The paper identifies conserved microproteins from upstream ORFs in yeast using Ribo-Seq and Nanopore data, showing they are subject to purifying selection.

Hydroxyurea induces ER stress and cytoplasmic protein aggregation

This study shows hydroxyurea induces ER stress and cytoplasmic protein aggregation through disulfide stress, leading to ER expansion and HSP accumulation.

A systematic screen identifies Saf5 as a link between splicing and transcription in fission yeast

The paper identifies Saf5 as a gene linking transcription and splicing in fission yeast through a genetic screen and functional analysis.

Perturbed fatty-acid metabolism is linked to localized chromatin hyperacetylation, increased stress-response gene expression and resistance to oxidative stress

The paper shows that fatty-acid synthesis defects in fission yeast lead to chromatin hyperacetylation, stress-response gene activation, and oxidative stress resistance.

Cdk9, Spt5 and histone H2B mono-ubiquitylation cooperate to ensure antisense suppression by the Clr6-CII/Rpd3S HDAC complex

The paper investigates the interaction between Cdk9, H2Bub1, and the Clr6-CII HDAC complex in regulating antisense and sense transcription in fission yeast.