Irene García-Gónzalez

This study shows that loss of Vhl in astrocytes disrupts astrocyte-endothelial crosstalk, leading to hemangioblastoma formation in VHL disease.

The paper shows that endothelial cells lacking VEGFR2 adapt and become dominant in veins, enabling VEGF-independent angiogenesis through molecular changes like venousization and upregulation of VEGFR1 and VEGFR3 ligands.

The paper identifies Notch glycosylation and Mycn upregulation as critical for endothelial-to-hematopoietic transition during HSC development.

This study shows that Notch signaling regulates arterialization by suppressing cell cycle and metabolism rather than driving differentiation.