Rui Benedito

This study shows mitochondrial haplogroups affect tumour growth and anti-tumour immunity through mitochondrial ROS and PD-1 signalling in mouse models.

This study identifies biomechanical changes in the tubular basement membrane as drivers of cyst formation in ADPKD, linking cilia and polycystin-1 function.

The paper identifies a molecular circuit involving C/EBP and Dlk1 that regulates fate plasticity in AT2 cells during lung development and injury.

This study shows that loss of Vhl in astrocytes disrupts astrocyte-endothelial crosstalk, leading to hemangioblastoma formation in VHL disease.

The paper shows that endothelial cells lacking VEGFR2 adapt and become dominant in veins, enabling VEGF-independent angiogenesis through molecular changes like venousization and upregulation of VEGFR1 and VEGFR3 ligands.

This study shows that PIK3CAH1047R mutation causes clonal expansion in capillary and venous endothelial cells but not in arterial cells, revealing stage-dependent responses and a protective mechanism against arterial damage.

The paper identifies biological principles governing postnatal aortic growth, showing it scales with the vertebral column and relies on differentiated cell proliferation rather than stem cells.

The paper identifies NOTCH1-JAG1 cis interactions regulated by RADICAL FRINGE that maintain hematopoietic stem cell fate during development.

This study shows that Vegfa isoforms differentially regulate endothelial cell proliferation via PI3K signaling, independent of MAPK (ERK) activation in zebrafish.

The paper identifies Notch glycosylation and Mycn upregulation as critical for endothelial-to-hematopoietic transition during HSC development.

This study shows that Notch signaling regulates arterialization by suppressing cell cycle and metabolism rather than driving differentiation.

This study identifies Notch's role in driving cell potency transitions during early mouse development, revealing novel targets and interactions with Hippo signaling.