Disrupted astrocyte-endothelial crosstalk drives hemangioblastoma lesions in VHL disease
Macarena De Andrés-Laguillo, Irene García-Gónzalez, Susana F. Rocha, Aroa Garcia-Cabero, Sandra Ruiz-Garcia, Luis Diago-Domingo, Aimane Danana, Lorena Cussó, Katrien De Bock, José Antonio Enrı́quez, Rui Benedito
This study shows that loss of Vhl in astrocytes disrupts astrocyte-endothelial crosstalk, leading to hemangioblastoma formation in VHL disease.
bioRxiv · Sep 15, 2025 · PreprintCancer Biology