Author

Christopher A. Vakulskas

Integrated DNA Technologies (United States)ORCID 0000-0001-8510-4332Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Garrett R. RettigiD· 2 shared Gavin KurganiD· 2 shared M. Kyle CromeriD· 2 shared Mark A. BehlkeiD· 2 shared Matthew Hebden PorteusiD· 2 shared Nicole M. BodeiD· 2 shared Ankush Goyal· 1 shared Benjamin J. LeschiD· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenomics

Garrett R. RettigORCID

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2 papers

Recent·Most cited

GenomicsMolecular TherapyPeer-reviewedFeb 15, 2023

Comparative analysis of CRISPR off-target activity discovery tools following ex vivo editing of CD34+ hematopoietic stem and progenitor cells

M. Kyle Cromer, Kiran R. Majeti, Garrett R. Rettig…·Matthew Hebden Porteus

This study compares CRISPR off-target detection tools using ex vivo edited CD34+ HSPCs, finding that HiFi Cas9 reduces off-target sites and some methods outperform others in sensitivity and specificity.

42 citationstop 5%

humanCRISPR screen

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Molecular BiologyNature MedicinePeer-reviewedMar 18, 2021

Gene replacement of α-globin with β-globin restores hemoglobin balance in β-thalassemia-derived hematopoietic stem and progenitor cells

M. Kyle Cromer, Joab Camarena, Renata M. Martin…·Matthew Hebden Porteus

This study replaces the HBA1 gene with HBB in β-thalassemia-derived HSPCs using CRISPR, normalizing globin ratios and restoring functional hemoglobin.

83 citationstop 1%

humanexperimental assay

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