Author

Renata M. Martin

Stanford MedicineORCID 0000-0003-2996-4260Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Developmental Biology· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Matthew Hebden PorteusiD· 3 shared Benjamin J. LeschiD· 2 shared Daniel P. DeveriD· 2 shared Joab CamarenaiD· 2 shared Nobuko Uchida· 2 shared Amir DailamyiD· 1 shared Anastasiia MasaltsevaiD· 1 shared Anders Laustsen· 1 shared

Activity by Year

2018-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersDevelopmental Biology

Matthew Hebden PorteusORCID

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4 papers

Recent·Most cited

Developmental BiologybioRxivPreprintOct 11, 2025

Discovery of a primed endothelial progenitor that requires VEGF/ERK inhibition to complete vein differentiation

Lay Teng Ang, Sherry Li Zheng, Kevin J. Liu…·Kyle M. Loh

The paper identifies a primed endothelial progenitor that requires VEGF/ERK inhibition to differentiate into vein endothelial cells, revealing a two-step process for vein development.

6 citations

humanmouse

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NeuroscienceMolecular Therapy — Methods & Clinical DevelopmentPeer-reviewedJan 22, 2025

Human striatal progenitor cells that contain inducible safeguards and overexpress BDNF rescue Huntington's disease phenotypes in R6/2 mice

Danielle A. Simmons, Sridhar Selvaraj, Tingshuo Chen…·Frank M. Longo

This study shows that human striatal progenitor cells overexpressing BDNF and with inducible safety switches improve HD symptoms in R6/2 mice.

3 citations

mouseexperimental assay

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Molecular BiologyNature MedicinePeer-reviewedMar 18, 2021

Gene replacement of α-globin with β-globin restores hemoglobin balance in β-thalassemia-derived hematopoietic stem and progenitor cells

M. Kyle Cromer, Joab Camarena, Renata M. Martin…·Matthew Hebden Porteus

This study replaces the HBA1 gene with HBB in β-thalassemia-derived HSPCs using CRISPR, normalizing globin ratios and restoring functional hemoglobin.

83 citationstop 1%

humanexperimental assay

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BioengineeringbioRxivPreprintJan 23, 2018

Selection-free, high frequency genome editing by homologous recombination of human pluripotent stem cells using Cas9 RNP and AAV6

Renata M. Martin, Kazuya Ikeda, Nobuko Uchida…·Matthew Porteus

This paper introduces a Cas9/AAV6 system for high-frequency genome editing in human pluripotent stem cells without selection markers, achieving up to 94% integration efficiency for large DNA cassettes.

DOI 10.1101/252163

humanwhole-genome sequencing

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