Francesco Pisani

This study identifies PTBP1's role in human neural stem cell fate by showing it can be transferred between cells via tunneling nanotubes and extracellular vesicles, affecting proliferation and differentiation.

The paper designs and tests peptides that bind claudin-5 to increase blood-brain barrier permeability, identifying a peptide that effectively enhances permeability in vitro.

The paper shows myeloma cells transfer dysfunctional mitochondria to BMSCs via tunneling nanotubes, enabling transmitophagy and resistance to apoptosis under OGD.

This study shows that tunneling nanotubes (TNTs) enable mitochondrial transfer between BBB cells, rescuing astrocytes from ischemia/reperfusion-induced apoptosis and highlighting pericytes' role in BBB preservation.