Nicola Gagliani

This study shows that RYR1 in CD4+ T cells is not essential for their pathogenicity in intestinal inflammation models despite affecting calcium signaling.

This study shows that the ISR/eIF2α pathway regulates cytokine mRNA translation in Trm cells, limiting their activity in homeostasis but enabling rapid response during inflammation or autoimmunity.

DISCERN improves cell clustering and subtype detection by reconstructing missing gene expression, identifying novel T cell types in COVID-19 and predicting disease severity.

GOAT is a deep learning tool for annotating organoids from microscopy images, showing high performance across diverse organoid systems.

This study uses spatial transcriptomics to map the transcriptomic landscape of healing murine colon, identifying spatially organized transcriptional programs and their association with human diseases.