Andreas H. Guse

Ryanodine receptor 1 is dispensable for CD4+ T-cell differentiation and effector function in intestinal inflammation models

This study shows that RYR1 in CD4+ T cells is not essential for their pathogenicity in intestinal inflammation models despite affecting calcium signaling.

JPT2/HN1L functions as an NAADP-binding protein in a cell type-specific manner

This study shows JPT2/HN1L is essential for NAADP-mediated Ca2+ release in T cells but not in cardiomyocytes, platelets, or mast cells.

Domain-Specific Agonist Binding Affinities Explain Structural and Functional Regulation of TRPM2

This study quantifies the binding affinities of TRPM2 domains for ADPR analogs and shows that MHR1/2 drives activation while NUDT9H maintains structural integrity.

Immune activation of primary human macrophages is suppressed by the coordinated action of Yersinia effectors

This study examines how Yersinia enterocolitica T3SS effectors modulate gene expression, inflammasome formation, and calcium signaling in human macrophages, revealing their antagonistic and synergistic effects on immune pathways.

Time-Dependent Image Restoration of Low-SNR Live Cell Ca2+ Fluorescence Microscopy Data

This paper introduces a variational image restoration method for low-SNR live cell Ca2+ fluorescence microscopy data, demonstrating its effectiveness across synthetic and biological datasets.