Author

Björn‐Philipp Diercks

University Medical Center Hamburg-EppendorfORCID 0000-0002-6635-1706Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:deconvolution· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Andreas H. GuseiD· 3 shared Alexander CarsteniD· 1 shared Alexander FlügeliD· 1 shared Christian LohriD· 1 shared Christine E. GeeiD· 1 shared Dmitri Lodygin· 1 shared Franziska MöckliD· 1 shared Friederike Stumme· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersImmunology

Andreas H. GuseORCID

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3 papers

Recent·Most cited

Ryanodine receptor 1 is dispensable for CD4+ T-cell differentiation and effector function in intestinal inflammation models

Sogol Dostiar Tabrizi, Mikołaj Nawrocki, Tanja Bedke, Marius Böttcher, Friederike Stumme, Melina Birus, Franziska Möckl, Lola Hernandez, Björn‐Philipp Diercks, Nicola Gagliani, Dmitri Lodygin, Alexander Flügel, Andreas H. Guse, Hans‐Willi Mittrücker, Samuel Huber

This study shows that RYR1 in CD4+ T cells is not essential for their pathogenicity in intestinal inflammation models despite affecting calcium signaling.

European Journal of Immunology · Aug 1, 2026Peer-reviewedImmunology

Immune activation of primary human macrophages is suppressed by the coordinated action of Yersinia effectors

Indra Bekere, Sören Rob, Jonas Lübbe, Susanne Kulnik, Laura Berneking, Jiabin Huang, Marie Schnapp, Björn‐Philipp Diercks, Andreas H. Guse, Alexander Carsten, Klaus Ruckdeschel, Martin Aepfelbacher

This study examines how Yersinia enterocolitica T3SS effectors modulate gene expression, inflammasome formation, and calcium signaling in human macrophages, revealing their antagonistic and synergistic effects on immune pathways.

mBio · Nov 24, 2025Peer-reviewedCell Biology

Time-Dependent Image Restoration of Low-SNR Live Cell Ca2+ Fluorescence Microscopy Data

Lena-Marie Woelk, Sukanya A. Kannabiran, Valerie J. Brock, Christine E. Gee, Christian Lohr, Andreas H. Guse, Björn‐Philipp Diercks, René Werner

This paper introduces a variational image restoration method for low-SNR live cell Ca2+ fluorescence microscopy data, demonstrating its effectiveness across synthetic and biological datasets.

International Journal of Molecular Sciences · Oct 30, 2021Peer-reviewedBioinformatics