Ulf Panzer

Spatio-temporal interaction of immune and renal cells determines glomerular crescent formation in autoimmune kidney disease

This study uses spatial transcriptomics to show that immune and renal cell interactions drive glomerular crescent formation in RPGN through PDGF and TGF-β signaling to PECs.

Spatial Analysis of T Cell Clonality in Autoimmune Kidney Disease Using TRV Probes

The paper develops an in situ hybridization method to analyze T cell clonality in kidney biopsies and finds spatial clustering of clonally related T cells near antigen-presenting cells.

Community-based biomedical context to unlock agentic systems

This paper introduces BioContextAI, an open-source initiative that provides standardized access to validated biomedical knowledge to improve the reliability of AI systems in biomedical research.

PCA-based spatial domain identification with state-of-the-art performance

This paper introduces NichePCA, a PCA-based method for spatial domain identification that performs competitively with ten state-of-the-art methods across six spatial transcriptomic datasets.