Piwi and piRNAs repress transcription of aberrant rRNA genes containing retrotransposon fragments
Elena A. Fefelova, Aleksei S. Shatskikh, Elena A. Mikhaleva, Yuri A. Abramov, Sergey A Lavrov, Сергей Анатольевич Пирогов, Valentin A. Poltorachenko, Artem A. Ilin, Phillip D. Zamore, Mikhail S. Klenov
The paper shows that Piwi and piRNAs repress transcription of defective rRNA genes with truncated retrotransposon insertions in Drosophila ovaries, preventing aberrant rRNA accumulation.
bioRxiv · Apr 30, 2025 · PreprintMolecular Biology