Paulino Ramirez

This study uses nanopore long-read sequencing to analyze genomic disruptions in Alzheimer's disease, finding increased retrotransposon activity and structural variants in aged brains.

The paper reports genome drafts of three Spiroplasma Citri clade strains associated with Drosophila, inferring limited metabolic capacities and diverse toxin repertoires compared to Poulsonii clade strains.

This study shows that pathogenic tau increases mRNA translation rate early in disease by altering NMD and promoting translation of neurodegeneration-linked mRNAs.

The paper identifies m6A-dependent circRNA dysregulation as a causal factor in tau-induced neurotoxicity using Drosophila and iPSC models.

This study shows that pathogenic tau accelerates transposable element activation in the aging mouse brain, particularly ERVs, suggesting a link between tauopathy and transposable element-induced neurotoxicity.

The paper identifies Moesin as a key effector of tau-induced neurotoxicity by disrupting neuronal identity through aberrant cell cycle activation in Alzheimer's disease and tauopathies.

The paper investigates whether heritable endosymbionts affect early embryo mRNA transcriptomes and finds no consistent influence, but detects rRNA depurination consistent with Ribosome Inactivating Proteins.