Bess E Frost

This study identifies emerin as a mediator of cytoskeletal remodeling in tauopathy by showing its elevation and relocalization in neuronal models of tauopathy, linking nuclear mechanotransduction to neurotoxicity.

This study uses nanopore long-read sequencing to analyze genomic disruptions in Alzheimer's disease, finding increased retrotransposon activity and structural variants in aged brains.

This paper investigates how EWS's RNA-binding domains interact with its low-complexity domain to influence condensate formation, revealing electrostatic and residue-specific interactions that underlie EWS self-association.

This study shows that pathogenic tau increases mRNA translation rate early in disease by altering NMD and promoting translation of neurodegeneration-linked mRNAs.

The paper identifies m6A-dependent circRNA dysregulation as a causal factor in tau-induced neurotoxicity using Drosophila and iPSC models.

The paper reprocesses R-loop mapping data, develops new quality methods, and introduces RLBase, a web server for exploring and analyzing R-loop datasets.

RLSuite provides a framework for analyzing R-loop data, including preprocessing, quality control, and comparison to public datasets.

The paper reprocesses R-loop mapping datasets to assess data quality and identifies consensus R-loop regions, revealing methodological differences and biological subtypes.

This study identifies JADE1 as a novel genetic factor in tauopathy through genome-wide association and functional validation in human and Drosophila models.

This study shows that pathogenic tau accelerates transposable element activation in the aging mouse brain, particularly ERVs, suggesting a link between tauopathy and transposable element-induced neurotoxicity.

The paper identifies Moesin as a key effector of tau-induced neurotoxicity by disrupting neuronal identity through aberrant cell cycle activation in Alzheimer's disease and tauopathies.