Shawn R. Lockery

Behavioral and genetic analysis of the effects of the psychedelic 2,5-dimethoxy-4-iodoamphetamine (DOI) in C. elegans

This study investigates the effects of the psychedelic DOI on C. elegans behavior, finding that it inhibits feeding independently of serotonin receptors, suggesting alternative mechanisms.

C. elegans food choice exhibits effort discounting-like behavior

This study shows that C. elegans exhibits behavior similar to effort discounting, where worms devalue harder-to-consume food options, mirroring economic models of cost-benefit decisions.

The nematode worm C. elegans chooses between bacterial foods as if maximizing economic utility

This study shows that C. elegans makes food choices as if maximizing subjective value, using a utility function similar to humans and requiring dopamine signaling.

The conserved endocannabinoid anandamide modulates olfactory sensitivity to induce hedonic feeding in C. elegans

This study shows that anandamide, an endocannabinoid, modulates feeding behavior in C. elegans by altering sensitivity to food quality, revealing functional conservation with mammalian systems.