Janice Mayne

This study uses metaproteomics to analyze how culture medium and donor-specific factors influence the establishment of in vitro fecal microbial communities over time.

The paper investigates how oligosaccharide structure and donor age influence gut microbiome function through ex vivo fermentation, metaproteomics, and metabolomics.

The paper uses metaproteomics to show that gut microbiomes have personalized functional responses to different oligosaccharides, highlighting the need for individualized prebiotic strategies.

This study maps metaproteomic responses of human gut microbiota to 312 drugs, identifying 47 compounds that significantly alter microbial protein profiles and reveal functional state shifts.

MetaLab enables comprehensive DDA and DIA metaproteomics analysis by supporting both modes without requiring DDA results, improving peptide identification in human gut microbiome studies.

This study introduces a streamlined TMT labeling method using pre-aliquoted dry reagents, improving efficiency and reducing variability in proteomic and metaproteomic analyses.

This study quantifies protein-level functional redundancy in the human gut microbiome using ultra-deep metaproteomics and network analysis, revealing high redundancy and environmental influences on functional organization.

The paper characterizes lysine acetylation in the human gut microbiome and identifies differential acetylation patterns in Crohn’s disease patients.

MetaLab 2.0 improves PTM identification and quantification in metaproteomics by providing an open search workflow with higher accuracy and sensitivity than traditional methods.

The paper introduces a chemoenzymatic method to quantitatively analyze N-glycan types on glycoproteins, demonstrating its application in characterizing glycan heterogeneity in IgG1 and MCF7 cells.