Marc Dieu

Mitochondrial dysfunction as a hallmark of brain senescence in telomerase-deficient mice

This study identifies mitochondrial dysfunction as a key feature of brain senescence in telomerase-deficient mice, linking telomere attrition to impaired mitochondrial function and region-specific neuronal vulnerability.

Identification of the cellular transcription factor KLF16 as a novel repressive epigenetic repressor of HIV-1 transcription

This study identifies KLF16 as a repressive transcription factor that inhibits HIV-1 transcription by competing with Sp1 and recruiting repressive complexes.

A subset of type 4 secretion system effectors of Brucella spp. associates to outer membrane vesicles

The paper identifies a subset of Brucella T4SS effector proteins that associate with outer membrane vesicles, suggesting an alternative secretion pathway.

Unraveling the pathway of Copper Delivery to Cytochrome c oxidases in the Free-Living Bacterium Caulobacter vibrioides

This study identifies distinct copper trafficking pathways for two cytochrome c oxidases in Caulobacter vibrioides, revealing an outer membrane receptor required for one and a periplasmic chaperone for the other.

A lipid transport Mla Pqi Chimeric system is essential for Brucella abortus survival in macrophages

This study identifies and characterizes the Mpc complex in Brucella abortus, showing its essential role in lipid transport between membranes and survival in macrophages.

Upregulation of the AcrAB2NodT efflux pump confers antibiotic resistance at the cost of collateral metal sensitivity

This study shows that overexpression of the AcrAB2NodT efflux pump in Caulobacter vibrioides confers antibiotic resistance but also causes metal sensitivity due to energetic costs.

An Early Olfactory Transcriptomic Signature of Tauopathy: Gbp2b Emerges as a Candidate Biomarker of Tau-Driven Neuroinflammation

The paper identifies Gbp2b as an early biomarker of tauopathy in the olfactory epithelium of PS19 mice through transcriptomic analysis across different ages.

Atypical features of the disordered N-terminal region of a bacterial outer membrane copper transporter.

The paper investigates the role of the disordered N-terminal region of PcoB in copper homeostasis and stability in Caulobacter vibroides, revealing its importance in Cu efflux and PcoA stabilization.

Novel insights into Emx2 and Dmrta2 cooperation during cortex development and evidence for Dmrta2 function in choroid plexus

This study investigates the cooperative role of Emx2 and Dmrta2 in cortex development and reveals distinct functions of Dmrta2 in choroid plexus formation.

Role of a TonB-dependent receptor and an oxygenase in iron-dependent copper resistance in Caulobacter crescentus

This study identifies CciT and CciO as key proteins involved in iron transport that confer copper resistance in Caulobacter crescentus by modulating cellular iron and copper levels.

LolA and LolB are conserved in Bacteroidetes and are crucial for gliding motility and Type IX secretion.

This study identifies LolB homologs in Bacteroidetes and shows they are involved in gliding motility and Type IX secretion, but lipoprotein transport can occur independently of LolA and LolB.

TamL is a key player of the outer membrane homeostasis in Bacteroidetes.

This study identifies TamL as essential for outer membrane integrity in Bacteroidetes, showing its role in maintaining membrane stability and interacting with TamB.

Evidence that Dmrta2 acts as a transcriptional repressor of Pax6 in murine cortical progenitors and identification of a mutation crucial for DNA recognition associated with microcephaly in human

This study shows Dmrta2 represses Pax6 in cortical progenitors and identifies a DNA-binding mutation linked to microcephaly in humans.

In-depth study of MPV17: a molecular travel unveiling a mitochondrial calcium regulation function

This study identifies MPV17 as a regulator of mitochondrial calcium and oxidative stress, showing its role in preventing mtDNA degradation through interactions with the MICOS complex.

An interdisciplinary study around the reliquary of the late cardinal Jacques de Vitry

The paper presents interdisciplinary analyses of the reliquary of Jacques de Vitry, confirming the remains belong to him and revealing unexpected diversity in the mitre's animal species.