GeneticsGenetic EpidemiologyPeer-reviewed
Constrained Instruments and their Application to Mendelian Randomization with Pleiotropy
Lai Jiang, Karim Oualkacha, Vanessa Didelez…·and for the Alzheimer’s Disease Neuroimaging Initiative
This paper introduces Constrained Instrumental Variable (CIV) methods to improve Mendelian randomization by handling pleiotropy, showing better performance in simulations and application to ADNI data.
23 citations