Karim Oualkacha

Simultaneous SNP selection and adjustment for population structure in high dimensional prediction models

This paper introduces ggmix, a penalized linear mixed model for SNP selection and population structure adjustment in high-dimensional genetic prediction models, showing improved accuracy and parsimony over existing methods.

Constrained Instruments and their Application to Mendelian Randomization with Pleiotropy

This paper introduces Constrained Instrumental Variable (CIV) methods to improve Mendelian randomization by handling pleiotropy, showing better performance in simulations and application to ADNI data.

Principal component of explained variance: an efficient and optimal data dimension reduction framework for association studies

This paper introduces an efficient PCEV framework for dimension reduction in association studies, showing improved computational efficiency and statistical power.