ImmunologybioRxivPreprint
Anchoring of perforin-2 via the transmembrane domain is required for endocytic escape in cross-presenting dendritic cells
Marco Laub, Ritika Chatterjee, Patrycja Kozik
This study shows that full-length, membrane-anchored perforin-2 is required for endocytic escape in cross-presenting dendritic cells, and that pore formation occurs with spatiotemporal precision.
DOI 10.64898/2025.12.03.692202