Olga M. Sigalova

The paper identifies cis-acting genetic variants affecting enhancer function in Parkinson's Disease using multi-omics data and develops models to predict their regulatory impact.

The paper identifies genetic variants affecting TF binding during Drosophila embryogenesis and uses a CNN to predict functional variants.

The paper introduces GRaNIE and GRaNPA, tools for inferring and evaluating enhancer-mediated gene regulatory networks in macrophages, identifying PURA as a regulator of pro-inflammatory polarization.

This study uses multiomics analysis of BMSCs to show age-related changes in enhancer activity and gene regulation contribute to immune traits and tissue-specific disorders.

The paper identifies genomic features predictive of gene expression variation across individuals and shows these features also predict differential expression under stress in Drosophila and humans.

The paper performs a pan-genomic analysis of Chlamydia species, showing genome stability with conserved core genes and evolvability in specific gene families due to host immune pressure.