Mattia Forneris

Heterotypic directional motifs contribute to TAD boundary function in Drosophila

The paper identifies directional motif pairs that determine TAD boundary compatibility in Drosophila, showing conservation from flies to mammals.

SPT5 regulates Pol II pausing and elongation in different ways at early versus late embryonic stages

This study shows SPT5 regulates Pol II pausing and elongation differently in early and late Drosophila embryogenesis, affecting gene expression dynamics.

Chip (Ldb1) is a new cofactor of Zelda forming a functional bridge to CBP during zygotic genome activation

The paper shows that Ldb1 (Chip) is a cofactor of Zelda that bridges to CBP to regulate gene expression during zygotic genome activation in Drosophila.

Contextualising transcription factor binding during embryogenesis using natural sequence variation

The paper identifies genetic variants affecting TF binding during Drosophila embryogenesis and uses a CNN to predict functional variants.

Predictive features of gene expression variation reveal a mechanistic link between expression variation and differential expression

The paper identifies genomic features predictive of gene expression variation across individuals and shows these features also predict differential expression under stress in Drosophila and humans.