Scott Victor Bratman

The paper uses cfMeDIP-seq to analyze cell-free placental DNA methylation in maternal plasma, identifying enriched regions associated with preterm birth and IUGR.

This study identifies DNA methylation instability in blood cells linked to aging and disease, showing age-related instability and associations with cardiovascular disease and cancer.

This study conducts a cross-ancestral GWAS and fine mapping of head and neck squamous cell carcinoma subsites, identifying 29 novel variants and highlighting gene-environment interactions.

The paper develops a method to simulate cell-free chromatin for epigenetic biomarker discovery, showing it better reflects tissue chromatin features than plasma-derived samples.

MEDIPIPE provides an automated pipeline for cfMeDIP-seq data quality control, methylation quantification, and sample aggregation, offering ease of use and scalability for large-scale analysis.

This paper introduces synthetic spike-in controls for cfMeDIP-seq to enable accurate and reproducible quantification of DNA methylation, reducing batch effects and technical biases.

This study develops RadioGx, a computational platform to analyze radioresponse in radiogenomic databases, identifying molecular pathways and drug correlations with radiation response.