Yong Zeng

iSHARC is a pipeline for analyzing scMultiome data, enabling quality control, integration, clustering, annotation, and regulatory analysis in cancer studies.

The paper identifies essential circRNAs in human cancer cells and introduces FunCirc, a database of functional circRNAs across cancer cell lines and tissues.

The paper introduces memo-eQTL, a method to identify DNA methylation-modulated eQTLs, and finds 1,731 novel memo-eQTLs in prostate samples that alter SNP-gene expression interactions through CTCF-based chromatin structure changes.

MEDIPIPE provides an automated pipeline for cfMeDIP-seq data quality control, methylation quantification, and sample aggregation, offering ease of use and scalability for large-scale analysis.