Timothy J. Jegla

The paper traces the evolutionary origins of human voltage-gated K+ channels, identifying which were present in common ancestors and which were lost, and functionally characterizes the missing channels from other vertebrates.

The paper identifies and functionally characterizes voltage-gated K+ channels in ctenophores, showing independent evolution of diverse subtypes similar to those in cnidarians and bilaterians.

The paper investigates the role of Kv12-encoded K+ channels in regulating day-night firing rate rhythms in SCN neurons, finding they drive the nighttime decrease in firing rates.