Jeanne M. Nerbonne

This study shows that a mutation in FGF14 causes haploinsufficiency and impairs Purkinje neuron firing, leading to motor and cognitive deficits in mice.

This study shows that loss of iFGF14 increases excitability of mature hippocampal and cortical pyramidal neurons by altering INaT voltage-dependence and action potential waveform.

The paper investigates the role of Kv12-encoded K+ channels in regulating day-night firing rate rhythms in SCN neurons, finding they drive the nighttime decrease in firing rates.

The paper investigates the gating mechanisms of resurgent Na+ currents in mouse cerebellar Purkinje neurons using voltage-clamp recordings and a novel computational model.

The paper identifies fragile physiological dynamics of ion channel kinetics associated with genomic determinants of arrhythmias and validates this relationship using RNA sequencing.