Li Deng

MetaTrass improves metagenome assembly by binning first and assembling later, producing more high-quality draft genomes from human gut microbiome samples.

The paper introduces a de novo scaffolding tool for synthetic long reads that improves assembly quality significantly, especially for assemblies from next-generation sequencing reads.

The paper introduces HAST, a tool for haplotype-resolved assembly using trio binning, achieving high accuracy and completeness in haplotype reconstruction from synthetic long reads.

The paper improves short read clustering for metagenome assembly by reducing under-clustering through sample-based statistics, showing effectiveness on mouse gut microbiome data.

This study examines intratumor heterogeneity and evolution patterns in colorectal cancer, finding a Darwinian pattern with differences between right-sided and left-sided tumors.

TGS-GapCloser closes gaps in genome assemblies using error-prone long reads, improving contig N50 and gene completeness while being faster than existing tools.