Sara M. O’Rourke

This study evaluates the diagnostic yield of long-read nanopore sequencing in rare disease detection, finding it covers more genes and detects additional variants compared to short-read sequencing.

This study identifies three novel neutralizing antibody epitopes on the human astrovirus capsid spike using structural biology techniques and shows their role in blocking virus neutralization.

The paper identifies the stem loop 2 motif as a vulnerable site in SARS-CoV-2 that can be targeted by antisense oligonucleotides to inhibit replication and infection.