Rebecca M. DuBois

This study identifies three novel neutralizing antibody epitopes on the human astrovirus capsid spike using structural biology techniques and shows their role in blocking virus neutralization.

This paper identifies three neutralizing monoclonal antibodies against HAstV-VA1 and maps their epitopes, revealing four antigenic sites and immune pressure-driven mutations in a patient with encephalitis.

The paper uses long-read RNAseq to identify and quantify complex isoforms in individual B cells, revealing widespread transcriptional variation in surface receptors and the antibody heavy chain locus.