Author

Ketan J. Patel

MRC Laboratory of Molecular BiologyORCID 0000-0001-8641-5802Unclaimed ORCID profile · follow to get notified of new preprints

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1

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Juri RappsilberiD· 1 shared Lori A. PassmoreiD· 1 shared Pablo AlcóniD· 1 shared Shabih ShakeeliD· 1 shared Zhuo Angel CheniD· 1 shared

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Molecular BiologyNature Structural & Molecular BiologyPeer-reviewedFeb 17, 2020

FANCD2-FANCI is a clamp stabilized on DNA by monoubiquitination during DNA repair

Pablo Alcón, Shabih Shakeel, Zhuo Angel Chen…·Lori A. Passmore

This paper determines the structure of FANCD2-FANCI (D2-I) using cryoEM, showing that monoubiquitination stabilizes its closed conformation on DNA, acting as a clamp for DNA crosslink repair.

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experimental assay

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