Lori A. Passmore

The paper shows phosphorylation modulates deadenylation rates via multivalent interactions in RNA adaptors, enabling graded regulation of mRNA decay.

The paper identifies a kinetic ruler mechanism where Nab2 protein concentration determines mRNA poly(A) tail length through competition between polyadenylation and RNA-binding.

This study shows that the PAN2-PAN3 deadenylation complex can be recruited to specific mRNAs via RNA adaptors, adding to the specificity of mRNA degradation.

This paper improves crosslinking mass spectrometry by using diazirine-based photo-crosslinking to better study dynamic protein regions and their conformational changes.

This paper shows how transcription termination via the CPF-like phosphatase module affects chromatin silencing of FLC in Arabidopsis, influencing flowering time.

The paper identifies how TTC5 recruits SCAPER to initiate tubulin mRNA degradation via interaction with the CCR4-NOT complex, linking ribosome-associated mRNA decay to microtubule regulation.

This study shows CPF interacts with Pol II and promotes its dimerization, linking RNA 3'-end processing to transcription termination.

This study identifies how human CCR4-NOT complex recognizes and ubiquitinates stalled ribosomes during mRNA decay in response to sub-optimal codons.

This study identifies RBBP6 as a critical factor required for human CPSF-mediated pre-mRNA 3'-end processing, showing its RNA-dependent recruitment and interaction with CPSF subunits.

This study investigates the dynamics of Fip1 in the CPF complex, showing its IDR remains highly dynamic and mediates conformational transitions during mRNA 3'-end processing.

The paper shows Mpe1 interacts with the polyadenylation signal in pre-mRNA to activate CPF and control polyadenylation in yeast.

This paper determines the structure of FANCD2-FANCI (D2-I) using cryoEM, showing that monoubiquitination stabilizes its closed conformation on DNA, acting as a clamp for DNA crosslink repair.

The paper shows that RNA-binding proteins selectively tether the Ccr4-Not complex to specific mRNAs through low-complexity sequences and RNA-binding domains, influencing mRNA stability.