Zhuo Angel Chen

MetaXtract extracts structured metadata from Thermo Fisher raw files to enhance FAIR data practices and workflow efficiency.

The paper shows phosphorylation modulates deadenylation rates via multivalent interactions in RNA adaptors, enabling graded regulation of mRNA decay.

This paper improves crosslinking mass spectrometry by using diazirine-based photo-crosslinking to better study dynamic protein regions and their conformational changes.

The paper identifies two factors, Q22YU3 and Q22MS1, that package axonemal outer dynein arms for ciliary targeting in Tetrahymena.

This study uses cryo-EM and biochemical experiments to reveal the mechanism of DNA entry into the cohesin ring, showing how ATP binding and hydrolysis regulate the process.

This paper determines the structure of FANCD2-FANCI (D2-I) using cryoEM, showing that monoubiquitination stabilizes its closed conformation on DNA, acting as a clamp for DNA crosslink repair.

This study develops QCLMS to detect protein conformational changes by analyzing cross-linking yields and introduces methods to distinguish minor and major changes.

The paper introduces an updated MaxQuant workflow for quantitative cross-linking/mass spectrometry (QCLMS) that improves cross-link quantification accuracy and reliability through automation and label-swap replicas.

This paper determines the structure of C3(H2O) using quantitative cross-linking/mass spectrometry and modeling, revealing domain rearrangements compared to C3 and C3b.