Cerys S Manning

The paper shows that oscillatory co-expression of HES1 and HES5 allows hybrid states in a bistable transcription factor motif by enabling phase-locking and entrainment.

The paper investigates YAP1 variants' role in ocular coloboma using in vitro and organoid studies, showing how missense variants affect YAP1-TEAD binding and transcriptional activity.

The paper investigates how cellular protrusions in mouse spinal cord neural progenitors enable long-distance Notch signaling, affecting HES5 expression patterns.

This paper introduces a Bayesian method to infer kinetic parameters of oscillatory gene regulation from single-cell time series data and demonstrates its effectiveness on murine neural progenitor cells.

The paper identifies spatially periodic HES5 microclusters in the mouse spinal cord during neurogenesis, showing their dynamic regulation by Notch signaling and their role in progenitor differentiation.

The paper shows that miR-9 levels increase stepwise during zebrafish neurogenesis through sequential activation of distinct pri-mir-9 loci, which helps overcome adaptation in Her6 dynamics.

The paper uses live imaging and mathematical modeling to show HES5 protein dynamics correlate with cell-state transitions and fate decisions in murine neurogenesis.