GenomicsCardiovascular ResearchPeer-reviewed
Histone demethylase KDM5 regulates cardiomyocyte maturation by promoting fatty acid oxidation, oxidative phosphorylation, and myofibrillar organization
Manisha Deogharia, Leslye Venegas-Zamora, Akanksha Agrawal…·Priyatansh Gurha
This study shows that KDM5 inhibition promotes iPSC-CM maturation by enhancing fatty acid oxidation, oxidative phosphorylation, and myofibrillar organization through epigenetic regulation of key genes.
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