Francisco J Altamirano

This paper demonstrates that human iPSC-derived engineered heart tissues can replicate tissue-scale mechanisms of ventricular tachycardia, including APD dispersion and reentry, previously only observed in intact hearts.

This study shows that PC1-CT in cardiomyocytes activates PI3K-Akt-mTOR-S6K1-S6 signaling to enhance protein synthesis pathways without inducing canonical hypertrophy.

This study shows that KDM5 inhibition promotes iPSC-CM maturation by enhancing fatty acid oxidation, oxidative phosphorylation, and myofibrillar organization through epigenetic regulation of key genes.