Abhinav K. Jain

This study shows BET + MAPK inhibitors improve efficacy against BRAFV600E CRC by inducing epigenetic reprogramming and cellular plasticity through enhancer dynamics disruption.

This study investigates BCL11A DNA binding mechanisms, epigenetic regulation, and small-molecule effects on its expression in human erythrocyte precursor cells.

This study shows KDM6A mutations in bladder cancer improve response to immune checkpoint therapy but worsen chemotherapy outcomes through effects on DNA repair and metabolic reprogramming.

This study shows that KDM5A is activated in heart failure and its deletion improves cardiac function and gene expression in a mouse model.

This study identifies quinoline-based compounds that inhibit DNA methyltransferases and other DNA-targeting enzymes, with compound 11 inducing DNA damage response in cancer cells.

This study shows that KDM5 inhibition promotes iPSC-CM maturation by enhancing fatty acid oxidation, oxidative phosphorylation, and myofibrillar organization through epigenetic regulation of key genes.

This study identifies an RNA binding module in the SWI/SNF complex that is essential for enhancer activation and cell-type specific gene regulation during early development.

This study shows that SMARCA4 regulates spatially restricted metabolic changes in 3D multicellular tissues by altering DNA accessibility and gene expression.

This study shows that DUX4 causes cell death and pathology in both in vitro and mouse models independent of p53, challenging the idea that p53 is central to DUX4's pathogenicity.