Author

Manisha Deogharia

The University of Texas Health Science Center at HoustonORCID 0000-0002-4685-3792Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Abhinav K. JainiD· 2 shared Ali J. MarianiD· 2 shared Priyatansh GurhaiD· 2 shared Akanksha AgrawaliD· 1 shared Chitra Lekha Reddy· 1 shared Christiane ZorbasiD· 1 shared Denis L. J. LafontaineiD· 1 shared Francisco J AltamiranoiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersGenetics

Abhinav K. JainORCID

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3 papers

Recent·Most cited

The Epigenetic Regulator Histone Demethylase KDM5A is Activated and Pathogenic in a Mouse Model of Heart Failure

Manisha Deogharia, Chitra Lekha Reddy, Ritapa Chaudhuri, Manogna Sai Chirasani, Abhinav K. Jain, Leila Rouhi, Ali J. Marian, Priyatansh Gurha

This study shows that KDM5A is activated in heart failure and its deletion improves cardiac function and gene expression in a mouse model.

bioRxiv · Jan 6, 2026 · PreprintGenetics

Intrinsically Disordered Regions Form Nucleoli and Cajal Bodies While Fostering RNA Modification

Koceila Meznad, Manisha Deogharia, Ludivine Wacheul, Christiane Zorbas, Denis L. J. Lafontaine, U. Thomas Meier

The paper shows that Nopp140 concentrates intrinsically disordered regions to form the DFC, a phase-separated condensate that enables efficient rRNA modification.

bioRxiv · Jun 18, 2025 · PreprintCell Biology

Histone demethylase KDM5 regulates cardiomyocyte maturation by promoting fatty acid oxidation, oxidative phosphorylation, and myofibrillar organization

Manisha Deogharia, Leslye Venegas-Zamora, Akanksha Agrawal, Miusi Shi, Abhinav K. Jain, Kevin J. McHugh, Francisco J Altamirano, Ali J. Marian, Priyatansh Gurha

This study shows that KDM5 inhibition promotes iPSC-CM maturation by enhancing fatty acid oxidation, oxidative phosphorylation, and myofibrillar organization through epigenetic regulation of key genes.

Cardiovascular Research · Jan 12, 2024Peer-reviewedGenomics