Kevin J. McHugh

This study develops SABER hydrogels that extend drug release and therapeutic effect for small molecules and biologics in preclinical models.

This paper demonstrates that Dopa crosslinking with lysine covalently stabilizes collagen mimetic peptides and their assemblies, enhancing thermal stability for biomedical applications.

This paper introduces two novel methods to incorporate DBCO into S. aureus peptidoglycan for SPAAC-mediated cargo labeling, showing improved stability and reduced toxicity compared to existing approaches.

This paper develops a prodrug system for targeted colonic delivery of budesonide using gut commensals, showing improved drug localization and reduced systemic side effects.

This paper conjugates a TLR7 agonist to a peptide hydrogel to create a vaccine adjuvant that produces antibody titers similar to alum and a more balanced Th1/Th2 immune response.

This paper describes a novel vaccination platform using crosslinking polymers to enhance humoral immunity and dendritic cell activation in lymph nodes without adjuvants.

This study shows that KDM5 inhibition promotes iPSC-CM maturation by enhancing fatty acid oxidation, oxidative phosphorylation, and myofibrillar organization through epigenetic regulation of key genes.