Circulating tumor cells shed shearosome extracellular vesicles in capillary bifurcations that activate endothelial and immune cells
Angelos Varotsos Vrynas, Salime Bazban‐Shotorbani, Sara Arfan, Karishma Satia, Brian C. Cunningham, Gauhar Sagindykova, Mymuna Ashna, Aoyu Zhang, Diana Visan, Aisher Chen, Teige R. S. Matthews-Palmer, Mathew Carter, Fiona Helen Blackhall, Kathryn L. Simpson, Caroline Dive, , Sam H. Au
This study shows circulating tumor cells shed shearosome extracellular vesicles in capillary bifurcations, which activate endothelial and immune cells and contribute to pre-metastatic niche formation.
Advanced Science · Jun 9, 2025Peer-reviewedCancer Biology