Kathryn Simpson

A three-dimensional imaging pipeline for the detection of vasculogenic mimicry in mouse tumor models

This paper introduces a 3D imaging pipeline to detect functionally perfused vasculogenic mimicry in mouse tumor models, providing evidence of its presence and functionality.

Circulating tumor cells shed shearosome extracellular vesicles in capillary bifurcations that activate endothelial and immune cells

This study shows circulating tumor cells shed shearosome extracellular vesicles in capillary bifurcations, which activate endothelial and immune cells and contribute to pre-metastatic niche formation.

Copper induces p53 unfolding in cancer cells, resulting in invasion and chemoresistance

The paper shows copper induces p53 unfolding in cancer cells, leading to invasion and chemoresistance, with partial restoration by the chelator Trien.