Author

Carla Castignani

The Francis Crick InstituteORCID 0000-0001-8689-9659Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:deconvolution· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Elizabeth Larose CadieuxiD· 2 shared Heli VaikkineniD· 2 shared Nana MensahiD· 2 shared Pawan DhamiiD· 2 shared Peter Van LooiD· 2 shared Stephan BeckiD· 2 shared Amy P. WebsteriD· 1 shared Andrew FeberiD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersCancer Biology

Elizabeth Larose CadieuxORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintDec 2, 2024

Epigenetic investigation of multifocal small intestinal neuroendocrine tumours reveals accelerated ageing of tumours and epigenetic alteration of metabolic genes

Amy P. Webster, Netta Mäkinen, Nana Mensah…·Christina Thirlwell

This study identifies epigenetic changes and accelerated ageing in multifocal small intestinal neuroendocrine tumours, revealing altered metabolic gene regulation and tumour-specific methylation patterns.

DOI 10.1101/2024.12.02.626017

humanDNA methylation

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GenomicsbioRxivPreprintNov 3, 2020

Copy number-aware deconvolution of tumor-normal DNA methylation profiles

Elizabeth Larose Cadieux, Nana Mensah, Carla Castignani…·Peter Van Loo

This paper introduces CAMDAC, a method to deconvolve tumor-normal DNA methylation profiles while accounting for copy number changes, revealing epigenetic instability and distinct patterns in lung cancer.

9 citations

humanDNA methylation

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