Heli Vaikkinen

The paper identifies activation of the innate immune stress pathway as a mechanism linking heterochromatin dysfunction to pathological phenotypes in C. elegans and human cells.

HCR3.0 RNA-FISH linked to RS-FISH spot detection labels transcripts in C. elegans embryos, larvae and adults, and yields per-neuron counts of short insulin-like peptide mRNAs in L2 larvae.

This study identifies epigenetic changes and accelerated ageing in multifocal small intestinal neuroendocrine tumours, revealing altered metabolic gene regulation and tumour-specific methylation patterns.

This study integrates single-cell RNA sequencing and spatial transcriptomics to map the temporal-spatial gene expression patterns during human pancreas development, identifying lineage dynamics and novel genes involved in beta cell maturation.

The paper benchmarks five DNA methylation platforms and shows imputation improves interoperability between them.

This paper introduces CAMDAC, a method to deconvolve tumor-normal DNA methylation profiles while accounting for copy number changes, revealing epigenetic instability and distinct patterns in lung cancer.

This study uses long-read sequencing to analyze VSG diversity in T. brucei infections, revealing higher expressed diversity and early mosaic gene formation than previously observed.

The paper identifies genetic factors and immune mechanisms associated with symptom severity in human African trypanosomiasis using transcriptome analysis and an animal model.